If you are following a pattern then the seam size will make a difference, but each machine will sew different 1/4" size seams; as will the same machine with different sewers will have a different size seam because each person sees edges differently. Do what is comfortable for you and the fabric and how your end project will be used. Baby or pet quilts might have a larger seam than the show quilt or wall hanging. Just enjoy the hobby of quilting that is all the really matters.