I'm assuminig you mean a cotton/polyester blend. And yes, sure you can use that for making quilts. You can use most anything you're willing to work with. There are no absolutes. But most women/men today prefer to use the 100% cottons as they are softer to the touch, not as "hot" against the skin, and easier to needle. Some quilters are absolute "purists" and wouldn't dream of using anything but cotton, but many others use a combination of fabrics. As long as you're using the same basic weights together, you should be ok. I've used cotton/poly in the past, but quite a few years ago I switched to using only cottons to make quilts. Make yourself happy. :)