QM

I would tend to finds a novelty fabric or panels that reflect interests. I particularly like very large 8 point stars with square panel centers, although I don't see one at the moment. Adam's quilt is one of a pair I designed for my new step grands. My neighbor simply alternates large squares of novelties and plain fabric for her DGSs.

Of course, printing photos, drawings, etc. is also a great way to individualize a quilt.