I've done it and it works fine. I've also used fleece as backing but ONLY if the blanket is tied rather than quilted. You can use it for backing and quilt it as long as you use some type of stretch stitch as your quilting stitch. I had some fabric that Jeeps on it and used just a length of it, backed it with fleece, tied it and made a wonderfully warm car blanket to carry in my Jeep. Used it at a church cook out one evening, loaned it to a visitor that was traveling through and she took it with her when she left. She must have really liked it.