Cut a 1/4" around the outline on the fusible, fuse it to the fabric and then when you are ready to iron it to the block/quilt, trim it on the drawn lines. This will keep fraying to a minimum.
Use larger/wider applique stitches on big pieces, and make the stitches narrower/shorter on the smaller pieces.
Try some of these combinations on a scrap fabric, and write down the settings you used next to them, so you can reference them later.
Stitch them down slow, stop and turn with your needle down frequently. Yes it can seem a pain at times, but it is still faster than sewing them by hand :wink:
Most of all, have fun with this technique :D:D:D