It might make a difference in the things you offer according to what part of the USA you're in, and if the LQS will be located in a large, medium, or small town.
In a rural town, it's normal to find most stores having "flexible" hours - which is difficult for a city person to get used to.
The location has to be chosen based on the customer base you want - and convenience for that market. Have you done a business plan and finished market research yet?