I have made a few of the big fluffy types- my kids prefer them & they are actually harder for me to do than a quilt with thinner batting. The thinner batting (Warm & Natural, 80/20, etc) is much easier to hand or machine quilt. I did machine a quilt I made out of the thickest batting (poly) I could find & it was a bear to do & I have a Janome 1600 machine that will sew through anything! I would think that most of the really thick quilts will have to be tied, which I have done too.