There's a natural, plant based hormone replacement I'm told.
I never took one, unfortunately.
I did have a lump in one boob one year at about age 46 or so, and one doctor told me to start taking low doses of Vitamin E, the real one, and work up the dose over months. My starting hot flashes sorta diminished and went away, got into other things and forgot about it.
One daughter (52 this week) keeps her house so cold that I wear a heavy house coat all the time I'm visiting her.
At home I keep it about 67 or so now.