I have been on Prednisone for almost a year now due to a autoimmune diease that I have. I have gained almost 40 lbs. Iam hungry all the time 20mins after I eat Iam ready again. Iam so thankful for a understanding husband. I dont know that I am tired all the time but i can say I am not overly ambitious. Sorry you have to take this yuck medication but hopefully it helps you and you can get off it soon.