I have never taken it, but my late husband had to take it at least once or twice a year. It really affected him badly. He said it felt like he was trying to crawl outside of his skin, and he was so jittery. He was also the most easy going person you would ever meet. Totally different story on prednisone. He acutally called a nurse a B.... and he would never, never, never have done this without the meds. The VA hospital finally had to let me help, and had to keep one nurse out of his room. I never knew how he would react to something with this drug.