I think it will work for OBW - just move the center of your medallion around so that you pick up different parts of the stripes. Some can be with the stripes in the sheet going from the center to the outside, and some can be with the stripes going around the medallion. You may not have such a dynamic variation in blocks with this sheet as you would with a floral, etc, but it will work and since it's your first one and you like the sheet, go for it.