i made a quilt with leather's, velvets, corduroys....lots of different textures/fabrics...the only down side to the quilt is laundering...if there is quite a bit of leather you have to pay big bucks to have it professionally leather cleaned...some dry-cleaners will not even accept it...it has to be sent somewhere. when i made mine i was careful that everything that was washable was washed ahead of time and was very careful putting it together. i have done some (spot-cleaning) on it a couple times...have thought about just taking a chance...but have not taken that step...so the quilt is...about 7-8 years old and so far has not been washed.....it's beautiful but not functional...mine is about 9" squares, some embellished, embroidered, stamped, .... mixed fab's all put together with dark velvet sashing strips; about 1/4 of the quilt top is leather squares. if you made the whole top with leather it would probably be easier to figure out a care-plan.