I hand quilt without a hoop. Pin frequently, start in the middle and work your way to the edges. Use a finger cot on your thumb because I find that it helps to pull the needle through easier. I also kepp a maximum of 4 stitches on the needle before pulling it through.that is just my preference. Use you hand underneath to constantly feel for puckers before they become a problem.
I'm left handed and that is how I do it.