I'm lazy, I never unhoop until I need to quilt a new area or am finished and I've never had a problem with creases. I also never pin baste a quilt I'm going to hand quilt (the thread will get tangled in the pins--pins are usually only used in machine quilting). If you look up Sharon Schambers video on hand quilting she has a basting technique that allows you to start quilting anywhere you want to--you don't have to start from the middle.