I usually quilted larger quilts in sections, but my first diamond log cabin star (93x104, so not as large as your quilt) couldn't be divided up that way. I wound up basting the whole thing with water soluble thread on the John Flynn frame (first and last time I used that frame, but it did the job) and then I did FMQ on my Bernina. The water soluble thread held it together really well so that I didn't have the additional weight and bulk of pins while I was quilting, plus I didn't have to take them out as I went or risk running over them (or sticking myself with them). I have never used the basting spray and would worry about it holding up with a quilt that large.
Prism99's idea should work even if the quilt is set on point. Marti Michell explains how to do on-point quilts in her book - really a good resource if you're going to quilt large quilts on a DSM.