I use 6 1/2 inch squares normally. I have used different patterns and colors. The large prints should be in your corners. I like a solid fabric for the little squares. But I have seen so many I like that are very different. I also like placing them so no seams touch
Here is one that I made with 4 inch squares
http://www.thriftyideastoday.com/201...ine-patch.html
I am going to redo this weekend. I really do not like the batting I used and also not thrilled of the binding color I choose.