I think it depends on what quilting pattern you are going to use. If it's the classic quilting (around each piece) that you are going to do, then I'd get all 4 colors and use each in accordance with the color patch. If you are going to do a fancier quilting pattern, I might go with a neutral beige. When I'm trying to decide, I take each spool and unwind about 2 or 3 yards and kind of lay it swirled on the top. One will probably stand out to you, and that's the one I'd choose. Good luck...