My male cat has always been very clean but one day he came out in my kitchen & urinated on the floor right in front of us. I took a urine sample into the vet and found out the poor buddy had diabetes! He was on insulin for about 6 months but after a lot of research and a diet change, he has been off insulin for more than a year. Unfortunately he has a developed what will probably be a terminal condition but right now he is his big old happy self!