What I would do is pin your rows together. For a 5" square, I would use only 1 pin, I like to pin at the top and the next one on the opposite side on the bottom. I hope I'm making sense. Then just sew the squares and rows that are pinned at the top or bottom, cut your threads, then sew the opposite sides. Press the rows after sewing, then sew the rows together. Press, then make your sandwich(backing, batting, and top). Tie, or quilt then do your binding. You could even do a pillowcase style, which means you don't have to do a binding. If you have any more questions or if I can help more or better, PM me.