Very interested in this as I have advanced arthritis in my left knee. Have been getting saline solution injections twice a year and they seem to help, or at least it hasn't gotten any worse. Don't really have pain, just discomfort and my mobility has been decreased, use a cane to keep weight of the 'bad' knee. 3 Steriod shots in the knee per year would be the next step when I have too much pain. What makes me leery about that treatment is the Ortho Drs. RN practioneer asked me if I have high blood pressure. Yes I do but controlling it with meds. Going to ask my primary Dr. about this at my appointment in a few weeks. Trying an over the counter flex meds but haven't experienced any change except a slighty upset stomach at times. May in Jerey