If you head into Asheville, there are several.
As far as quilt shops there is Asheville Cotton Co. If you head a little farther away, Marti's Patchwork Cottage is a cute little shop in downtown Black Mountain.
Foam & Fabrics and House of Fabric both carry a decent collection of quilting fabrics too.
Asheville Cotton Co., Foam & Fabrics, and House of Fabric are all on the same road, spread out by several miles, and the road changes names several times.