You have gotten a lot of good suggestions. Since the biggest key seems to be PRACTICE, PRACTICE, PRACTICE, PATIENCE, PRACTICE, PRACTICE, I thought I would share my experiences.
1. you definitely need those quilter's gloves. They really reduce the stress on the body and helps move the fabric.
2. I use basting spray, even on queensize quilts. I actually think it works better than pinning and those little tack guns. If you have a big design wall, it would be easier to spray baste. First get the back smooth, then spray, then put on the batting starting at the top and working your way out and down, then do the same with your top.
3. Start in the center and quilt it in quarters like you would handquilt.
4. Always pull your thread from the bottom when you start.
5. Have a lot of bobbins ready.
6. Coats and Clarks machine quilting thread is probably the least expensive but it does leave a lot of lint in your machine and you should clean your machine before and after your quilting.
7. Do a few wall hangings and lap quilts first. Depending on your machine, you may have to work with your tension, etc. to get your stitches right.
8. Use a print backing that won't show your mistakes as easily.
9. Don't worry about what it looks like. Just do it. Your next one will be better with.......practice.
10. This probably should have been number 1. Don't use polyester batting. It doesn't lay flat. For FMQ it is better to use cotton batting or cotton batting with a little bit of polyester. It is just way too hard to FMQ on polyester, especially when you are a beginner.
I can't wait to see your first one.