All of the above with regard good quality is worth it, shrinkage, pre-washing a must in my opinion, lots of fuzz so keep machine clean, and it stretches more.
A few more things to add ... rotary cutting blades and needles will get more wear. Also necessary to wash your cutting board more often - I even use the edge of my 6.5" ruler to scrape it then wash it with with a damp cloth.
Last, when I work with flanel I use flanel for batting! 1 thickness will do. The whole quilt when done has a lovely "hand" with the flanel batting - very supple so it's great for "tucking" into. Not to oheavy but plenty warm.