Sometimes you just have to "woman-handle" it. I've done a large queen-size quilt, but have a king-size ready to start and have procrastinated for several months. One idea that someone shared with me was to quilt it in 3 sections. This is what I will try because I use 45" fabric for the backing. I'll cut batting at 45" too and sandwich just the center panel and then sew on the backing and batting for one side and then do the other. Does that make sense? Haven't tried it on my own, but I think it will work.