I started quilting my tops with the 1st top I made. I used a walking foot and sewed straight/diagonal lines 1/4" on either side of a seam. I eventually graduated to using a free motion foot (or a darning foot) and started doing stippling and free motion leaves and feathers. The 1st quilt I made was a queen-sized quilt. I call that my pucker quilt - since it was my first quilt I had lots of errors in seam allowances and ended up with puckers on top and bottom. I still use it (under the top cover on my bed). While you can do large quilts, it can become difficult to manage a large bunch of quilt on your sewing machine. But, by all means - GO FOR IT! I finally purchased a mid-arm and frame last March, but some of the lessons I learned quilting on my domestic sewing machine were invaluable.