A few years ago I made a baby quilt with minkee. Rotary cutting is fine but I do not remember cutting it in layers. Biggest tip is before you sew a seam, flick the raw edge with your fingernail. Lots of fuzz comes off and be sure and clean your machine when you are finished. Lots of people use it for the backing of baby quilts and I have never heard of any problems with it or in the quilting process. Enjoy making those baby quilts.
Rita