I use quite a bit on various project. I do not think I would use it on a full size quilt , or a bed quilt. The interfacing does restrict the fabric from being able to "puff", and move. Its great for wall hangings as the extra support keeps everything nice and square.
If I did do a full bed size , I would do it in blocks , and attach the blocks together, it would be a lot easier to handle, and the fusible sometimes lets go of the fabric squares prior to sewing. This would be a particular problem on a full size quilt. The intersections are bulky , now you will have four layers of fabric and four of interfacing. This will be problematic when it comes time to quilt it. I find starch ( some times lots of it) will accomplish more of what I need, and less bulk.
Its fun to play with ... But I use it on small stuff.
I have been known to use it on large 1/2 triangle ot keep those bias's behaving. But shhhh... don't tell ! :)