If you are able to quilt in all directions without moving the quilt around, go for the frame (and as long as you have space for it, too).
I have a hoop. I can move it from room to room (keeping it away from kids and I don't have the space for a frame - yet), and since I can't quite quilt in all directions (still figuring some of that out) this is what I prefer. I also like to keep the quilt loose in the hoop instead of tight, don't know if I can do that in a frame). I find I don't prick my fingers as often.
This probably wasn't much help...
Good luck with your decision, it's a tough one.