It depends, what do you want from your batting? What sort of use will the quilt get? Is it a baby quilt, a bed quilt, a wall hanging? Are you hand-quilting or machine-quilting? Will the quilt need to be washed a lot? Do you want a batting that will shrink after washing? Do you want a puffy batting or a thin, low-loft one? A lot of people love Warm and Natural, for instance, but I don't use it because there are better battings for hand-quilting and I don't want any shrinkage. It really is a personal thing.