I'm origanally from Buffalo and when I go back these are on the top of my list.
My favorite are :
Favorite Fabrics - Orchard Park NY ( an online , but they let you come in and shop) ... awesome selection great prices, staff is very frendly . Do check the hours prior as an on -line does not have same as a regular retail store.
The Quilt Farm - Not too far from Fav Fabrics - Really diverse selction , great location in the farm country , really in a converted barn .. its full of fabric. You will think you are lost when you go to this one.
Homespun Boutique - Ithaca- nice selection of quilt fabrics, garment fabrics , and awesome yarn.
Quilters Corners - Ithaca - On the same street as Homespun ( State street) .