Yes, but with a little help. You will need 5 strips of 2.5" for binding, that uses up 12.5 inches. The backing needs to be 2" larger on each side for shifting, etc, unless it is going to a long-arm then you may need more. So you need a 46 x 52 piece for the back. You start with 2 yards = 72", cut off the binding, you have aprox 59.5 left. Cut a 42 x 52 " piece, you have about 9.5" left witch means you have a 42 x 7.5" left. You can then add an extra block or two to that to get to the 52" you need and then sew that onto the 42 x 52 piece. and you will have approx 49 x 52 " back. Your extra piece of "somthing" will need to be approx 10"in length to be able to make up the extra space. See Barnbum's back from yesterday to see what I mean, sort of. Hope this helps