I have done both in a quilt. I hand quilt in areas where the stitching will be noticed- not where the print will hide the work. If you have areas that the fabric is really busy, particularly towards the outer edges of the quilt- go for it. To me, it makes the outer edges of the quilt very sturdy- good for wear and tear if the quilt will be used and loved. Now, if you are going to enter a competition, I wouldn't. If it is for daily use, go for it.