I am making my AOTH with regular fabrics. I am making a test block in 12" size, it is almost finished. My quilt will be 10" blocks so it will fit my bed. From my stash, there could be enough make every piece out of a different fabric. I used to buy lots of 6" block sets which really gives many choices for applique. As far as enlarging the blocks, the ones with many pieces could be made 15" to 18" without loosing the integrity of the design.