Pigzrule219

I have a very dear friend who found out last week her husband has cancer. He beat colon cancer a few years back but now it is in his liver, which they figure came from the original cancer. He will be going through chemo to shrink the softball size tumor so it can be removed surgically. If all goes well, the doctor said he has another good 10-15 years at least. They have a horse farm and I wanted to make a lap quilt for him to use while going through treatments etc.
I found this horse panel on ebay and fell in love with it. Very realistic to me. My problem is trying to decide what pattern to do around the main panel to enlarge it. The main panel is 25 1/2"x 18 1/2" Then I thought I would take the smaller picture's which are 6"x6", frame them out for the 4 corners. I will have 2 small picture's left so I will either frame them to put down the sides or leave them out.
Should I do a D9P, D4P, 4 patch,9 patch totally different pattern than these make it bigger? I think you get the idea. Any help, ideas and suggestions would be greatly appreciated.
Now let's see if I can get these picture's loaded. This is a first for me on this site.
Thank you all in advance.