Many good suggestions above.
Great Dream. Start making your dream a reality. Take a couple of business management classess.
Start a notebook of all your ideas. This will eventually become part of your business plan. take notebook with you everywhere & write in it.
Explore quilt shops outside your area. Talk to owners. What would they do differently. Are they profitable.
Take your dream one step at a time.
Are there any quilt shops in your area? Do not duplicate their style. Create your own.
Check out rent. Municipal laws & requirements.
Are you physically prepared to work long hours?
Are there enough quilters, sewers in your area to support a quilt shop.
Are you prepared for the finanicial investment and possible debt?
Good Luck