Yes you can! My daughter traced some pictures out of a coloring book, just an outline and then colored the pictures for a quilt for her son. After you finish coloring, with just regular crayons, put something protective over the picture to protect your iron and iron it. The ironing sets the colors for you. She did 9 of them and then I sashed them for her and finished putting it together. You can wash and dry it as normal. I have a kit that I keep meaning to get started on that is a flower bouquet that you color and make a wall hanging out it. I thought about when my grandson and granddaughter get a bit older I will trace an outline of some pics on 12" squares, let them color them and then make them some lap quilts out of it. It's very fun.