Since I just spent the weekend putting binding on two quilts, I can tell you what I do.
I make a french binding (long strips folded in half lengthwise and then sew on the top of the quilt.) I fold the folded edge over and slip stitch it, careful that not only does the thread blend with the backing, but that the stitches don't show. I stitch about every 1/8 of an inch, and I make a knot every few inches to help keep it secure.
Hope this helps.