You really can do anything. Here is a log cabin quilt which I'm about half way through quilting (by hand). It's 49" square with 11" blocks, it's one of the more unstructured sorts of log cabins (I call it a crazy log cabin), and the quilting style is Welsh quilting.
Turquoise/green crazy log cabin, top only by
Elettaria, on Flickr
Welsh design 1 by
Elettaria, on Flickr
See? Anything is possible!