I also have done large quilts on my "regular" machine.
What might really help you is if you can create a large table space to the left and back of your machine. I found that without a lot ot table top room, the quilting process was so much more of a fight.
That will make it much more manageable. Then, roll up the quilt sandwich really as tightly as you can on the right (throat) side.
Many "teachers" suggest stay stitching in the ditch initially then go back and work on smaller areas. The "shifting of the backing and batting will be minimized. That has been helpful for me also.
Looking forward to seeing what other suggestions come forth.