I'm in Jessamine County. We've got 3 quilt stores in Fayette County - one in Hamburg shopping center (exit 108), one off Nicholasville Road, and my favorite on Harrodsburg Road near the Jessamine County Line. The other two are only about 15 - 20 minutes off the interstate. I can give more precise directions if you want. I just finished my degree at EKU, so I'm quite familiar with driving back and forth from the Richmond area.
EDITED: Just realized you said the drive to Lex was a bit much. I work in Lex (even though I live in Jessamine County) and with having driven 2 - 4 times a week to EKU for nearly 2 years, I forgot how much of a drive it is if you're not doing it on a regular basis for something. Welcome anyway. Where is the store you're familiar with? I didn't realize there was one in Madison County.