I sometimes get this without wearing eye makeup. On my eyelids. I just keep them clean & use Aquafor on them and it goes away. If you think it is makeup, it might need to be replaced. Eye Shadow & Mascara is bad about germs & bacteria. I have had to go to Lancolme makeup. I do switch brands of face wash & face cleaners once every year. I alternate with Lancolme & Origins. Good Luck and I hope you find the source of the problem.