I guess it would depend a little on how you plan to quilt it. Maybe it would be best to make a little sandwich and test your quilting method before you start on the real thing. I'm assuming there's fabric already on both sides of the pre-quilt, and that's extra bulk to sew through after you add your top. The pre-quilts that I'm familiar with have a rather lofty polyester batting, which also might give it a different look, or make the quilting go differently if you're used to something else.