If your quilt is going to be a wall hanging, and you will be quilting on a regular sewing machine you will be OK. If you are doing your quilting on a long arm, you might have thread breakage issues.
Personally, I wouldn't use rayon emb thread on a quilt that is going to be used as a bed quilt. Nor in one that will go into the washer. Rayon doesn't hold its color if you add bleach to the washer, or if there is bleach in the detergent.
Just my thoughts.