From past experience, I have not had good luck with cotton/poly blends. For starters, they don't make a nice crisp crease when pressing. They also have a tendency to beard - batting comes through over time & pills all over the blend's surface. I made a king-size Trip Around the World back in the early 80s - before I knew what I was doing. The pilling drove me crazy as I was using one of those sweater shavers on it all the time.
I also think they dull your blades more quickly & same for your machine needles.
This is just my opinion.