I've made a number of baby/young children quilts using my serger. I use two basic patterns - log cabin & 9 patch and all of them I did using the 'quilt as you go' technique. Yes they are a bit thicker but with fresh sharp needles, no sweat and done up really quick. I also finish out the edges using my serger on all of the quilts I make before binding - makes a nice clean base to start with.
Now I'm going to try the snowball using my serger but not as a 'quilt as you go' - way too many pieces for this quilter.
As in all things, just have fun and play with it. That's how new technigues are discovered and shared every day.