I go horizontally side to side and generally add in a stripe of different fabric so it means that I have two seams, but neither are in the exact middle of the quilt when folding. And i love the different "pop" of color.
Here are two samples of what I did....
But most of my quilts are less than 72 inches wide....so it works to get 4 yards and cut it into 2 yard pieces.....so they are each 72x44.... and it ends up a bit more than 72 x 88 inches.