I have done all my quilts on my Janome 6600, everything from a large lap quilt to several generous kingsize. Yes, it is tedious and difficult, but, it is also alot of fun.You have to push & pull it, scrunch & bunch it, but, in the end it was still alot of fun. I only did a couple with actual FMQ and had a little more difficulty with that, so my DH bought me a Tin Lizzie. But, with the Janome 6600, I always echoed my seams 1/4" and echoed any appliqued and I always loved the results. So, YES, you can quilt a large quilt on your domestic machine.