I did FMQ on a king size on my domestic machine. It was only my 4th quilt. Roll half the quilt very tight and start quilting in the middle. You can roll or fold the other side. Make sure it is loosely bunched in your lap to avoid to much pull on the fabric. Then turn it the other way and repeat. It really helps to have a large table (such as a large dining table) pushed up against the wall and have another table (card table)to your left to hold the quilt as you sew.
For a period of time we lived in a small apartment and only had a card table for dining so I put my rolling cutting table up against the bed (it is higher than most)to hold the quilt as I sewed and stood to do the quilting.
I think rolling the quilt to fit in the machine throat and having a large space to hold the quilt to keep it from pulling is the most important aspect.
Hope this helps.