I'm working on one right now that has a lot of buttons, and so far it hasn't been a problem. I've been able to work my hoop around the buttons. I may not be that lucky throughout the whole quilt, but if I do run into a problem, I may just choose to do that section without the hoop. Where I can use the hoop, however, I will. It's the most comfortable way for me to hand quilt.
Is your quilt covered evenly with buttons and beads or are there some empty spaces that might lend themselves to a hoop if you're careful with the placement? In the lap works too! It's just not the way I learned, so I try to use a hoop whenever I can. Hopefully you'll find what works for you. :)