My animals have pretty much free reign in our house, though I do try my best to keep them off my fabrics. One of our male cats is a stinker, though, and has figured out how to get into one of the shelves to nap.
I have never had a problem with any of them spraying or marking, and I wash everything before it leaves my hands. I also take a lint roller to items before I package them.
My studio door is closed when I am not in there, and my websites all say 'not pet-free environment'. Noone is allowed to smoke in the house, ever. (I am a non-smoker, hubby is quitting, but we have friends who smoke, so they're relegated to the back porch for butt breaks).